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Which Is Safer: Ozempic or Rybelsus?

Home  >  News  >  Which Is Safer: Ozempic or Rybelsus?

April 28, 2025 | By LitigationConnect
Which Is Safer: Ozempic or Rybelsus?

Medications like Ozempic and Rybelsus have become widely recognized in recent years. Both drugs belong to a class of medications known as GLP-1 receptor agonists and are often prescribed to manage type 2 diabetes. Increasingly, these drugs are also used off-label for weight loss. While many individuals have seen promising results, there are growing concerns about the safety of these drugs and the risks they may pose to your health.

If you or someone you love has been prescribed one of these medications, it’s essential to understand the potential risks and side effects associated with them. 

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A Quick Overview of Ozempic and Rybelsus

Before we compare their safety, it’s helpful to understand what these two medications are, how they work, and why they are prescribed:

Ozempic

Ozempic (semaglutide) is an injectable medication approved by the FDA for the treatment of type 2 diabetes. By helping regulate blood sugar, Ozempic can reduce the risks of complications like heart disease, nerve damage, and kidney issues. Its active ingredient, semaglutide, mimics the hormone GLP-1, which stimulates insulin production, reduces glucose released by the liver, and slows digestion to prevent blood sugar spikes.

Besides diabetes management, Ozempic has also gained widespread attention as a weight loss drug due to its ability to reduce appetite and promote a feeling of fullness.

Rybelsus

Rybelsus is another medication that contains semaglutide, but unlike Ozempic, it is taken orally in the form of a daily pill. Designed for individuals with type 2 diabetes, Rybelsus works similarly to Ozempic by helping manage blood sugar levels. Its oral formulation makes it a preferred choice for those who may not want to administer injections.

Like Ozempic, Rybelsus has been increasingly used off-label for weight loss. However, higher doses required for weight management have raised questions about long-term safety.

While both medications share the same active ingredient, the way they’re administered and the risks they pose can differ. Now, let’s explore the safety profiles of these drugs in depth.

Understanding the Risks and Side Effects

Every medication comes with potential side effects, and GLP-1 receptor agonists like Ozempic and Rybelsus are no exception. While many people tolerate these drugs well, others experience adverse effects that may range from mild to serious. Knowing what to watch for can make all the difference in protecting your health.

Common Side Effects

For both Ozempic and Rybelsus, the most frequently reported side effects include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Stomach pain

These gastrointestinal issues are relatively common because the drugs slow digestion. While they can often be managed with dietary changes or adjustments to dosage, some people may find them severe enough to discontinue treatment.

Serious Side Effects

Ozempic and Rybelsus have been linked to more serious health problems, some of which may be life-altering. Below, we’ll explore these risks in greater detail:

  • Gastroparesis (Stomach Paralysis)

Both medications have been associated with gastroparesis, a condition where the stomach doesn’t empty its contents properly. This condition can lead to symptoms like bloating, nausea, vomiting, and abdominal pain. For some individuals, gastroparesis can severely impact their quality of life, requiring medical interventions such as dietary changes or even surgery. The risk of developing gastroparesis appears to increase with higher doses of semaglutide, which are often prescribed for weight loss rather than diabetes management. This is a major concern when evaluating the safety of both drugs.

  • NAION Vision Loss

Another rare but alarming side effect linked to these drugs is Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION). NAION is a condition that interrupts blood flow to the optic nerve, potentially leading to sudden vision loss. While NAION is not commonly reported, the consequences can be devastating for those affected. Unfortunately, there is no way to reverse the damage caused by NAION.

  • Deep Vein Thrombosis (DVT)

Research suggests a possible link between semaglutide drugs and an increased risk of blood clots, including deep vein thrombosis (DVT). DVT occurs when a blood clot forms in a deep vein, typically in the legs, and can cause pain, swelling, and serious complications if the clot travels to the lungs, leading to a pulmonary embolism.

  • Gallbladder Disease

Prolonged use of Ozempic and Rybelsus may result in gallbladder issues, such as gallstones or gallbladder inflammation. These conditions can cause severe pain and may require surgical intervention to remove the gallbladder.

Understanding the risks doesn’t mean you should panic, but it does underscore the importance of staying informed about the medications you take. If you experience any of these side effects while on Ozempic or Rybelsus, you should consult a healthcare provider promptly.

Are the Risks Greater with Ozempic or Rybelsus?

When comparing the overall safety of Ozempic versus Rybelsus, several factors come into play. While both medications share the same active ingredient, the difference in how they’re administered can influence their safety profiles.

Ease of Administration

Ozempic is a once-weekly injection, which may reduce the likelihood of forgetting doses. However, some individuals may find injections inconvenient or intimidating, leading them to prefer Rybelsus, which is taken orally once daily.

That said, the oral formulation of Rybelsus can be less effective at delivering semaglutide into the bloodstream. As a result, higher doses are often required, which may amplify the risk of side effects.

Risk of Gastroparesis

Both medications pose a risk for gastroparesis, but the problem may be more pronounced with Rybelsus, especially at higher doses used for weight loss. If you already have digestive issues or are considering these medications for weight management, discussing the potential for gastroparesis with your doctor is crucial.

Potential for Vision Loss

Reports of NAION vision loss have been associated with both medications, but occurrences remain rare. Because this condition results in permanent vision damage, even a small risk is significant. If you have a history of optic nerve conditions, you may want to reconsider using these drugs.

Gallbladder and Cardiovascular Risks

Gallbladder disease and DVT risks appear to be comparable between Ozempic and Rybelsus. The key factor is the length of use. Prolonged use at high doses exacerbates the risk, making careful monitoring essential.

Individual Tolerances and Pre-Existing Conditions

Ultimately, how an individual responds to these medications can vary greatly. Factors like age, pre-existing health conditions, weight, and even genetic predispositions may influence whether Ozempic or Rybelsus poses a greater risk to your health.

What You Can Do to Stay Safe

If you or a loved one uses Ozempic or Rybelsus, you can take specific steps to use these medications more safely:

  1. Have a Candid Conversation With Your Doctor: Before starting either medication, share your full medical history with your healthcare provider. This will help identify potential risks related to your specific health conditions.
  2. Monitor Side Effects Closely: Pay attention to early warning signs like persistent digestive issues, eye problems, or leg pain that could indicate serious complications.
  3. Follow the Recommended Dosage: Taking higher doses than prescribed can significantly increase your risk of adverse effects. Always follow your doctor’s dosage instructions.
  4. Discuss Your Goals: If you’re using Ozempic or Rybelsus for weight loss rather than diabetes, make sure this choice is medically supported and not solely based on off-label recommendations.
  5. Stay Educated About Updates: Ongoing research may uncover new information about these medications. Stay informed so you can advocate for your health effectively.

Empowering yourself with knowledge is crucial. Your safety and well-being deserve to be a top priority, and it’s okay to ask questions or seek second opinions if something doesn’t feel right.

When Medications Cause Lasting Harm

For some individuals, the side effects of these medications have gone beyond inconvenience or discomfort, resulting in severe health problems that permanently affect their lives. If that’s your story, please know you’re not alone.

Many people in similar situations find comfort and empowerment in understanding their legal rights. Drug manufacturers have a responsibility to not only create safe products but to also provide adequate warnings about potential risks. When they fail to do so, the consequences can be serious, and they should be held accountable.

The Importance of Legal Representation if You’ve Suffered Side Effects from Ozempic or Rybelsus

For some individuals, the side effects of these medications have gone beyond inconvenience or discomfort, resulting in severe health problems that permanently affect their lives. If you or a loved one has experienced serious side effects from Ozempic or Rybelsus, it’s natural to feel concerned, frustrated, and even betrayed by the trust you placed in these medications. Coping with health challenges is hard enough without the added burden of uncovering answers or holding a powerful pharmaceutical company accountable. 

This is where legal representation becomes crucial—not just for pursuing justice, but for helping you regain some sense of control during an incredibly challenging time.

Holding Manufacturers Accountable

Pharmaceutical companies have a responsibility to ensure their drugs are safe and provide clear warnings about potential risks. When they fail to uphold this obligation, the consequences can be catastrophic for individuals and families. By pursuing legal representation, you can help shine a light on these failings and hold these corporations accountable for their negligence.

Taking legal action doesn’t just help you; it can also create lasting change. Many lawsuits against drug manufacturers have led to stronger regulations, drug recalls, and warnings that ultimately protect others from harm. Together, individuals like you who stand up for their rights can demand transparency and higher accountability within the pharmaceutical industry.

Navigating a Complex Legal Landscape

Drug-related lawsuits, particularly those involving mass torts or class actions, are often incredibly complex. They require a deep understanding of medical evidence, regulatory standards, and legal procedures. For someone unfamiliar with the system, navigating these cases can feel like an impossible task, especially while managing the emotional and physical effects of serious side effects.

Experienced legal professionals are invaluable in this process. They understand how to build a compelling case, whether by gathering medical records, consulting with expert witnesses, or explaining how your injury connects to the drug in question. They’ll also handle the intricate legal paperwork and negotiations, ensuring every detail is addressed so you can focus on your health and recovery.

Securing the Compensation You Deserve

Drug-related injuries often lead to mounting medical expenses, lost income, and a decline in your quality of life. Legal representation can play a pivotal role in helping you recover financial compensation to address these damages. Compensation may cover:

  • Medical bills for treatments, surgeries, or long-term care
  • Lost wages if you’ve been unable to work due to your condition
  • Pain and suffering resulting from your injury or diminished quality of life
  • The emotional toll taken on your family as they support you through recovery

While no amount of money can truly make up for the harm you’ve endured, compensation can ease the financial strain and provide resources for rebuilding your life.

How LitigationConnect Can Help

At LitigationConnect, we understand how daunting it can feel to stand up against a large corporation on your own. That’s why we’ve made it our mission to connect individuals harmed by medications like Ozempic and Rybelsus with legal professionals with extensive experience handling mass tort and product liability cases. Our trusted network of attorneys has the experience and resources needed to guide you through this process with compassion and commitment.

If you’ve suffered due to these medications, reach out to LitigationConnect today at (833) 552-7274 or through our online form for a free, no-obligation consultation. By empowering you with knowledge and connecting you with the right legal support, we’re here to help you take the first step toward accountability and justice. Your voice matters, and together, we can help ensure it’s heard.

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Table Of Contents

  • Contact Our Team Today
  • A Quick Overview of Ozempic and Rybelsus
  • Understanding the Risks and Side Effects
  • Are the Risks Greater with Ozempic or Rybelsus?
  • What You Can Do to Stay Safe
  • When Medications Cause Lasting Harm
  • The Importance of Legal Representation if You’ve Suffered Side Effects from Ozempic or Rybelsus
  • How LitigationConnect Can Help
  • Contact Our Team Today

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